Baroreflex modulation of peripheral vasoconstriction during progressive hypothermia in anesthetized humans

Abstract

Mild hypothermia is a major concomitant of surgery under general anesthesia. We examined the hypothesis that baroreceptor loading/unloading modifies thermoregulatory peripheral vasoconstriction and, consequently, body core temperature in subjects undergoing lower abdominal surgery with general anesthesia. Thirty-six patients were divided into four groups: control group (C), applied positive end-expiratory pressure (PEEP; 10 cmH2O) group (P), applied leg-up position group (L), and a group of leg-up position patients with PEEP starting 90 min after induction of anesthesia (L + P). The esophageal temperature (Tes) and the forearm-fingertip temperature gradient, as an index of peripheral vasoconstriction, were monitored for 3 h after induction of anesthesia. Mean arterial pressure and pulse pressure did not change during the study in any group. The change in right atrial transmural pressure from the baseline value was 0.3 ± 0.1 mmHg in C, −3.0 ± 0.5 mmHg in P, and 2.3 ± 0.4 mmHg in L ( P < 0.01). The change in Tes at the end of the study was −1.7 ± 0.1 (35.1 ± 0.1)°C in C, −1.1 ± 0.1 (35.7 ± 0.1)°C in P, and −2.7 ± 0.1 (34.1 ± 0.1)°C in L, showing significant differences ( P < 0.01). The Tes threshold for thermal peripheral vasoconstriction was 35.6 ± 0.1°C in C, 36.2 ± 0.2°C in P, and 34.8 ± 0.2°C in L ( P < 0.01). Excessive Tes decrease in the leg-up-position operation was attenuated by applying PEEP (L + P group; P < 0.05). Our data indicate that baroreceptor loading augments and unloading prevents perioperative hypothermia in anesthetized and paralyzed subjects by reducing and increasing the body temperature threshold for peripheral vasoconstriction, respectively.