The ins and outs of angiotensin processing within the kidney-Reference-Cited by-同舟云学术

The ins and outs of angiotensin processing within the kidney

Published:2014-09-01 Issue:5 Volume:307 Page:R487-R489
ISSN:0363-6119
Container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
language:en
Short-container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Author:

Wilson Bryan A.¹,Marshall Allyson C.¹,Alzayadneh Ebaa M.¹,Chappell Mark C.¹

Affiliation:

1. Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Abstract

The kidney is a key target organ for bioactive components of the renin-angiotensin system (RAS); however, various renal cells such as the tubular epithelium contain an intrinsic RAS. The renal RAS can be functionally divided into ANG II-AT1 receptor and ANG-(1–7)-AT7/Mas receptor arms that functionally oppose one another. The current review considers both extracellular and intracellular pathways that potentially govern the formation and metabolism of angiotensin peptides within the renal proximal tubules.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/ajpregu.00177.2014

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