Differential regulation of sympathetic burst frequency and amplitude following acute hypoxia in humans

Author:

Steinback Craig D.1,Kevin Shoemaker J.23

Affiliation:

1. Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada; and School of

2. Kinesiology and

3. Department of Physiology and Pharmacology, Western University, London, Ontario, Canada

Abstract

Current evidence suggests that the persistent sympathetic nerve activity (SNA), commonly observed after exposure to hypoxia (HX), is mediated by chemoreceptor sensitization and or baroreflex resetting. Evidence in humans and animals suggests that these reflexes may independently regulate the frequency (gating) and amplitude (neuronal recruitment) of SNA bursts. In humans ( n = 7), we examined the regulation of SNA following acute isocapnic HX (5 min; end-tidal Po2 = 45 Torr) and euoxic hypercapnia (HC; 5 min; end-tidal Pco2 = +10 from baseline). HX increased SNA burst frequency (21 ± 7 to 28 ± 8 bursts/min, P < 0.05) and amplitude (99 ± 10 to 125 ± 19 au, P < 0.05) as did HC (14 ± 6 to 22 ± 10 bursts/min, P < 0.05 and 100 ± 12 to 133 ± 29 au, P < 0.05, respectively). Burst frequency (26 ± 7 bursts/min, P < 0.05), but not amplitude (97 ± 12 au), remained elevated 10 min post-HX. The change in burst amplitude (but not frequency) was significantly related to the measured change in ventilation ( r2 = 0.527, P < 0.001). Both frequency and amplitude decreased during recovery following HC. These data indicate the differential regulation of pattern and magnitude of sympathetic outflow in humans with sympathetic persistence following HX being specific to burst frequency and not amplitude.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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