Novel regulator of vasopressin secretion: phoenixin

Author:

Gasparini Silvia1,Stein Lauren M.1,Loewen Spencer P.2,Haddock Christopher J.1,Soo Jasmine1,Ferguson Alastair V.2ORCID,Kolar Grant R.3,Yosten Gina L. C.1,Samson Willis K.1

Affiliation:

1. Department of Pharmacology and Physiology, Saint Louis University, St. Louis, Missouri

2. Centre for Neuroscience Studies, Queen’s University, Kingston, Ontario, Canada

3. Department of Pathology, Saint Louis University, St. Louis, Missouri

Abstract

The newly described hypothalamic peptide, phoenixin, is produced in the hypothalamus and adenohypophysis, where it acts to control reproductive hormone secretion. Both phoenixin and its receptor GPR173 are expressed in the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei, suggesting additional, nonreproductive effects of the peptide to control vasopressin (AVP) or oxytocin (OT) secretion. Hypothalamo-neurohypophysial explants released AVP but not OT in response to phoenixin. Intracerebroventricular administration of phoenixin into conscious, unrestrained male and female rats significantly increased circulating AVP, but not OT, levels in plasma, and it increased immediate early gene expression in the supraoptic nuclei of male rats. Bath application of phoenixin in hypothalamic slice preparations resulted in depolarization of PVN neurons, indicating a direct, neural action of phoenixin in the hypothalamus. Our results suggest that the newly described, hypothalamic peptide phoenixin, in addition to its effects on hypothalamic and pituitary mechanisms controlling reproduction, may contribute to the physiological mechanisms regulating fluid and electrolyte homeostasis.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de recherche en santé du Canada)

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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