Author:
Nomoto Shigeki,Ohta Minoru,Kanai Setsuko,Yoshida Yuki,Takiguchi Soichi,Funakoshi Akihiro,Miyasaka Kyoko
Abstract
The circadian rhythm of the body core temperature (Tc) and the effects of changes in ambient temperatures on the homeostasis of Tc in Otsuka Long Evans Tokushima Fatty (OLETF) rats, which are naturally occurring cholecystokinin (CCK)-A receptor (CCK-AR) gene knockout (−/−) rats, were examined. In addition, the peripheral responses to warming or cooling of the preoptic and anterior hypothalamic region (PO/AH) were determined. The circadian rhythm of Tc in OLETF rats was similar to that in Long-Evans Tokushima (LETO) rats; this rhythm was characterized by a higher Tc during the dark period and a lower Tc during the light period. When the ambient temperature was changed within the limits of 0°C to 30°C, the changes in Tc of LETO rats were associated with the changes in ambient temperature, whereas those in OLETF rats were dissociated from the temperature changes. The OLETF rats showed a large hysteresis. The peripheral responses to warming or cooling of PO/AH, including shivering of the neck muscle and changes in skin temperature of the tail and footpad, were similar in OLETF and LETO rats. To confirm the role of CCK-AR in the regulation of body temperature, the values of Tc in the CCK-AR(−/−) mice were compared with those in CCK-B receptor (CCK-BR) (−/−), CCK-AR(−/−)BR(−/−), and wild-type mice. In the mice, the circadian rhythms of Tc were the same, regardless of the genotype. Mice without CCK-AR showed larger hysteresis than mice with CCK-AR. From these results, we conclude that the lack of CCK-AR causes homeostasis of Tc in rats and mice to deteriorate.
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
17 articles.
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