Author:
Tarpey Margaret M.,Wink David A.,Grisham Matthew B.
Abstract
Facile detection of reactive oxygen and nitrogen species in biologic systems is often problematic. This is a result of the numerous cellular mechanisms, both enzymatic and nonenzymatic involved in their catabolism/decomposition, the complex and overlapping nature of their reactivities, as well as the often limited intracellular access of detector systems. This review describes approaches to the direct and indirect measurement of different reactive metabolites of oxygen and nitrogen. Particular attention to a method's applicability for in vivo determinations will be addressed.
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
546 articles.
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