Weight loss in adult male Wistar rats by Roux-en-Y gastric bypass is primarily explained by caloric intake reduction and presurgery body weight

Author:

Hoornenborg C. Warner12ORCID,Somogyi Edit13,Bruggink Jan E.1,Boyle Christina N.4ORCID,Lutz Thomas A.4ORCID,Emous Marloes5ORCID,van Beek André P.2,Nyakas Csaba13,van Dijk Gertjan1

Affiliation:

1. Department of Behavioral Neuroscience, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands

2. Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands

3. School of PhD Studies, University of Physical Education, Budapest, Hungary

4. Institute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland

5. Department of Bariatric and Metabolic Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands

Abstract

Relative to feeding an LF diet, continued feeding an HF/S diet does not negatively impact recovery from RYGB surgery in rats. Relative to feeding an LF diet, continued feeding an HF/S diet promotes RYGB-induced weight loss. The RYGB-induced weight loss is primarily explained by reduced cumulative EI and higher preoperative body weight, leading to comparably low levels of body fat content in HF/S and LF feeding rats.

Publisher

American Physiological Society

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