Angiotensin II attenuates the natriuresis of water immersion in humans

Author:

Schou Morten1,Gabrielsen Anders1,Bruun Niels Eske1,Skøtt Peter1,Pump Bettina1,Dige-Petersen Harriet1,Frandsen Erik1,Bie Peter1,Warberg Jørgen1,Christensen Niels Juel1,Norsk Peter1

Affiliation:

1. Department of Aviation Medicine, The Heart Centre, The National University Hospital, DK-2100 Copenhagen; Department of Medical Physiology, University of Copenhagen, DK-2200 Copenhagen; Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, DK-2600 Glostrup; Department of Internal Medicine and Endocrinology, Herlev University Hospital, DK-2730 Herlev; Department of Cardiology, Gentofte University Hospital, DK-2900 Hellerup; and Department of Physiology and Pharmacology,...

Abstract

The hypothesis was tested that suppression of generation of ANG II is one of the mechanisms of the water immersion (WI)-induced natriuresis in humans. In one protocol, eight healthy young males were subjected to 3 h of 1) WI (WI + placebo), 2) WI combined with ANG II infusion of 0.5 ng · kg−1 · min−1 (WI + ANG II-low), and 3) a seated time control (Con). In another almost identical protocol, 7–10 healthy young males were investigated to delineate the tubular site(s) of action of ANG II by the lithium clearance method (CLi) and were on an additional fourth study day subjected to infusion of ANG II at a rate of 1.5 ng · kg−1 · min−1(WI + ANG II-high). During WI + placebo, plasma concentration of ANG II decreased from 16 ± 2 to 8 ± 1 pg/ml ( P < 0.05) and renal sodium excretion increased from 104 ± 15 to 294 ± 27 μmol/min ( P < 0.05). During WI + ANG II-low, plasma ANG II was not suppressed by WI, and the natriuresis was blunted by 52 ± 13% ( P < 0.05). During WI + ANG II-low and WI + ANG II-high, an increase in CLi was prevented that was otherwise observed during WI, and fractional distal reabsorption of sodium was facilitated. In conclusion, maintaining plasma concentration of ANG II unchanged at the level of control attenuates the natriuresis of WI considerably in humans. Therefore, suppression of generation of ANG II is an important mechanism of the natriuresis of WI in humans. Furthermore, infusion of ANG II during WI prevents an otherwise induced increase in CLi and facilitates the fractional distal reabsorption of sodium, probably via an effect on aldosterone release.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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