Alterations of whole body glucose metabolism in a feline SARS-CoV-2 infection model-Reference-Cited by-同舟云学术

Alterations of whole body glucose metabolism in a feline SARS-CoV-2 infection model

Published:2024-06-01 Issue:6 Volume:326 Page:R499-R506
ISSN:0363-6119
Container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
language:en
Short-container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Author:

Rochowski Matthew T.¹²^ORCID,Jayathilake Kaushalya¹,Balcerak John-Michael¹,Tamil Selvan Miruthula³,Gunasekara Sachithra³,Rudd Jennifer³^ORCID,Miller Craig³,Lacombe Véronique A.¹²^ORCID

Affiliation:

1. Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, United States

2. Harold Hamm Diabetes Center, Oklahoma City, Oklahoma, United States

3. Department of Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, United States

Abstract

Our study on a feline model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, mirroring human COVID-19, revealed alterations in whole body and cellular glucose metabolism. Infected cats developed mild hyperglycemia, increased protein levels of glucose transporters in the lung, and AMPK activation in the heart. These findings suggest that SARS-CoV-2 infection induces metabolic reprogramming in the cardiorespiratory system to support viral replication. Understanding these mechanisms could lead to novel antiviral therapeutic strategies.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpregu.00228.2023

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