Endothelium-derived ET-1 and the development of renal injury-Reference-Cited by-同舟云学术

Endothelium-derived ET-1 and the development of renal injury

Published:2015-11-01 Issue:9 Volume:309 Page:R1071-R1073
ISSN:0363-6119
Container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
language:en
Short-container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Author:

De Miguel Carmen¹,Pollock David M.¹,Pollock Jennifer S.¹

Affiliation:

1. Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama

Abstract

The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/ajpregu.00142.2015

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