Mind the food: rapid changes in antioxidant content of diet affect oxidative status of chimpanzees

Abstract

The link between dietary antioxidants and oxidative status has been studied extensively in humans. Surprisingly, comparative data are not available from closely related species, such as chimpanzees, which evolved in environments characterized by strong fluctuations in the availability and quality of vegetable food sources. We tested the hypothesis that an abrupt decrease in dietary antioxidants would increase oxidative damages in captive chimpanzees ( Pan troglodytes), while a rapid increase in antioxidant intake would decrease oxidative damages accrued while on the low-antioxidant diet. An abrupt decline of dietary antioxidants increased urinary levels of lipid peroxides and of oxidative DNA damage but not of 8-isoprostanes. In contrast, an increased intake of dietary antioxidants did not affect the oxidative status. Chimpanzees that were both older and with a higher dominance rank had lower urinary levels of lipid peroxides and of DNA damage as compared with younger chimpanzees. Neither individual sex nor proportion of time being groomed explained any variation in all three markers of oxidative status. Finally, we found significant within-individual repeatability of all markers of oxidative status over the course of the experiment, suggesting a significant contribution of individual history to molding oxidative status. Our results show that antioxidant intake plays a nonnegligible role in the regulation of oxidative status homeostasis in our closest relatives, the chimpanzees. Our work also suggests that rapid short-term increases in antioxidant intake might not have the desired immediate impact on oxidative status, such as in the case of clinical interventions or training programs.