Distinct patterns of fat metabolism in skeletal muscle of normal-weight, overweight, and obese humans

Author:

Velan S. Sendhil,Said Nicholas,Durst Christopher,Frisbee Stephanie,Frisbee Jefferson,Raylman Raymond R.,Thomas M. Albert,Rajendran Vazhaikkurichi M.,Spencer Richard G.,Alway Stephen E.

Abstract

The link between body weight, lipid metabolism, and health risks is poorly understood and difficult to study. Magnetic resonance spectroscopy (MRS) permits noninvasive investigation of lipid metabolism. We extended existing two-dimensional MRS techniques to permit quantification of intra- and extramyocellular lipid (IMCL and EMCL, respectively) compartments and their degree of unsaturation in human subjects and correlated these results with body mass index (BMI). Using muscle creatine for normalization, we observed a statistically significant ( P < 0.01) increase in the IMCL-to-creatine ratio with BMI ( n = 8 subjects per group): 5.9 ± 1.7 at BMI < 25, 10.9 ± 1.82 at 25 < BMI < 30, and 13.1 ± 0.87 at BMI > 30. Similarly, the degree of IMCL unsaturation decreased significantly ( P < 0.01) with BMI: 1.51 ± 0.08 at BMI < 25, 1.30 ± 0.11 at 25 < BMI < 30, and 0.90 ± 0.14 at BMI > 30. We conclude that important aspects of lipid metabolism can be evaluated by two-dimensional MRS and propose that degree of unsaturation measured noninvasively may serve as a biomarker for lipid metabolic defects associated with obesity.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Reference44 articles.

1. Anonymous. Unsaturated Fatty Acids, Nutritional and Physiological Significance. The Report of the British Nutrition Foundation's Task Force. London: Chapman and Hall, 1993.

2. Trafficking of Dietary Fat in Lean Rats

3. Musculoskeletal spectroscopy

4. Role of proton MR for the study of muscle lipid metabolism

5. In vivo determination of intra-myocellular lipids in human muscle by means of localized1H-MR-spectroscopy

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