Older Type 2 diabetic males do not exhibit abnormal pulmonary oxygen uptake and muscle oxygen utilization dynamics during submaximal cycling exercise

Abstract

There are reports of abnormal pulmonary oxygen uptake (V̇o2) and deoxygenated hemoglobin ([HHb]) kinetics in individuals with Type 2 diabetes (T2D) below 50 yr of age with disease durations of <5 yr. We examined the V̇o2 and muscle [HHb] kinetics in 12 older T2D patients with extended disease durations (age: 65 ± 5 years; disease duration 9.3 ± 3.8 years) and 12 healthy age-matched control participants (CON; age: 62 ± 6 years). Maximal oxygen uptake (V̇o2max) was determined via a ramp incremental cycle test and V̇o2 and [HHb] kinetics were determined during subsequent submaximal step exercise. The V̇o2max was significantly reduced ( P < 0.05) in individuals with T2D compared with CON (1.98 ± 0.43 vs. 2.72 ± 0.40 l/min, respectively) but, surprisingly, V̇o2 kinetics was not different in T2D compared with CON (phase II time constant: 43 ± 17 vs. 41 ± 12 s, respectively). The Δ[HHb]/ΔV̇o2 was significantly higher in T2D compared with CON (235 ± 99 vs. 135 ± 33 AU·l−1·min−1; P < 0.05). Despite a lower V̇o2max, V̇o2 kinetics is not different in older T2D compared with healthy age-matched control participants. The elevated Δ[HHb]/ΔV̇o2 in T2D individuals possibly indicates a compromised muscle blood flow that mandates a greater O2 extraction during exercise. Longer disease duration may result in adaptations in the O2 extraction capabilities of individuals with T2D, thereby mitigating the expected age-related slowing of V̇o2 kinetics.