Effects of subfornical organ lesions on acutely induced thirst and salt appetite

Author:

Thunhorst Robert L.1,Beltz Terry G.1,Johnson Alan Kim1

Affiliation:

1. Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407

Abstract

We examined the role of the subfornical organ (SFO) in stimulating thirst and salt appetite using two procedures that initiate water and sodium ingestion within 1–2 h of extracellular fluid depletion. The first procedure used injections of a diuretic (furosemide, 10 mg/kg sc) and a vasodilator (minoxidil, 1–3 mg/kg ia) to produce hypotension concurrently with hypovolemia. The resulting water and sodium intakes were inhibited by intravenous administration of ANG II receptor antagonist (sarthran, 8 μg ⋅ kg−1 ⋅ min−1) or angiotensin-converting enzyme inhibitor (captopril, 2.5 mg/h). The second procedure used injections of furosemide (10 mg/kg sc) and a low dose of captopril (5 mg/kg sc) to initiate water and sodium ingestion upon formation of ANG II in the brain. Electrolytic lesions of the SFO greatly reduced the water intakes, and nearly abolished the sodium intakes, produced by these relatively acute treatments. These results contrast with earlier findings showing little effect of SFO lesions on sodium ingestion after longer-term extracellular fluid depletion.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 17 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Blood-borne interleukin-1β acts on the subfornical organ to upregulate the sympathoexcitatory milieu of the hypothalamic paraventricular nucleus;American Journal of Physiology-Regulatory, Integrative and Comparative Physiology;2018-03-01

2. Neural circuits underlying thirst and fluid homeostasis;Nature Reviews Neuroscience;2017-06-22

3. Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice;American Journal of Physiology-Regulatory, Integrative and Comparative Physiology;2017-06-01

4. Body Fluid Homeostasis;Hormones, Brain and Behavior;2017

5. DREADD-induced activation of subfornical organ neurons stimulates thirst and salt appetite;Journal of Neurophysiology;2016-06-01

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