Affiliation:
1. Arctic Aeromedical Laboratory, APO 731, Seattle, Washington
Abstract
Pentobarbital-anesthetized dogs, cooled in ice water to terminus, were found to have a 96% incidence of ventricular fibrillation. Plasma potassium levels were uniformly depressed at low body temperatures. Treatment with Intravenous potassium chloride, 150– 250 mg/kg, reduced the frequency of fibrillation to 57%. Administration of EDTA (ethylene diamine tetracetic acid), 75 mg/kg in divided doses, lowered serum calcium levels but affected the incidence of fibrillation only slightly. Combined therapy with potassium chloride and EDTA reduced the incidence of ventricular fibrillation to 50%. These results are interpreted as indicating that ionic imbalance observed with hypothermia produces a marked arrhythmic tendency and that proper alteration of plasma potassium levels reduces the danger of fibrillation. Submitted on July 28, 1958
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
14 articles.
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