Affiliation:
1. Systems Neurobiology Laboratory, Departments of Physiological Science and Neurobiology, University of California, Los Angeles, California 90095-1527
Abstract
Mellen, Nicholas M., and Jack L. Feldman.Vagal stimulation induces expiratory lengthening in the in vitro neonate rat. J. Appl. Physiol. 83(5): 1607–1611, 1997.—Respiration is modulated by lung mechanoreceptor feedback in vivo on a cycle-to-cycle basis. We replicated this modulation in vitro and tested four stimulus protocols to identify which of these most closely replicated in vivo responses to lung mechanoreceptor activation in mammals. We activated pulmonary vagal afferent pathways by electrical stimulation or by lung inflation, applied during expiration, which produces expiratory lengthening in vivo. In each modality, transient and tonic stimuli were applied. Stimuli were applied over a range of delays following inspiratory termination. Tonic stimuli were maintained until subsequent inspiratory onset. All stimulus modalities prolonged expiration ( P < 0.05). These results indicate that the neural circuitry mediating pulmonary afferent modulation of expiratory duration is retained in vitro.
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献