Author:
Gnidec A. G.,Sibbald W. J.,Cheung H.,Metz C. A.
Abstract
Since severity of acute lung injury (ALI) is reduced by pretreatment with non-steroidal agents, we hypothesized that ibuprofen would ameliorate ALI when administered after the onset of septic lung injury. Twenty-four hours after cecal ligation and perforation (CLP) in 23 sheep during a 4 h study period (period S), pulmonary lymph flow (QL) increased 16.2 +/- 12.1 ml/min (P less than 0.01) from base line, whereas lymph-to-plasma total protein concentration ratios ([L/P]TP) remained unchanged. During the subsequent 24 h of study (period D), 10 sheep received parenteral ibuprofen, 12.5 mg/kg every 6 h, and 13 sheep served as untreated septic controls. Throughout period D, a progressive increase in QL (16.2 +/- 16.3 ml/60 min) from period S was greater in the untreated than in the ibuprofen (2.5 +/- 9.0 ml/60 min, P less than 0.02) group. Between base line and period D, increase in lung wet-to-dry weight ratios was greater in the untreated group than in the ibuprofen group (P less than 0.05). Concurrently mean pulmonary arterial pressure increased 4.7 +/- 7.3 mmHg in the untreated group (P less than 0.05) during period D vs. 0.0 +/- 5.2 mmHg in the ibuprofen group (NS). When administered after septic ALI had been established by CLP, ibuprofen reduced an otherwise progressive increase in both fluid flux and extravascular lung water.
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
44 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Mechanistic Understanding of Lung Inflammation: Recent Advances and Emerging Techniques;Journal of Inflammation Research;2022-06
2. Animal Models of Increased Lung Vascular Permeability;Textbook of Pulmonary Vascular Disease;2010-12-03
3. The Critically Ill Patient;Critical Care Nephrology;2009
4. Animal models of acute lung injury;American Journal of Physiology-Lung Cellular and Molecular Physiology;2008-09
5. William J. Sibbald: In Memoriam;Critical Care Medicine;2007-01