Affiliation:
1. Department of Physiology, State University of New York Downstate Medical Center, Brooklyn, New York
Abstract
The effect of endogenous CO2 from exercising muscles and exogenous CO2 from CO2 inhalation was investigated in six pairs of cross-circulated dogs. The exercising hindlimbs of one dog (neural) were perfused exclusively from a second dog (humoral). The ventilatory response of the neural dog during exercise followed the predicted isometabolic hyperbola toward hyperventilation, whereas the ventilation of the humoral dog followed closely the relationship which existed between V and PaCOCO2 during CO2 inhalation. When the neural dog was given CO2 mixtures during steady state of induced exercise, its ventilation increased in a rectilinear function of the PaCOCO2. The V, PaCOCO2 line intersects the isometabolic curve for the exercise level at a PaCOCO2 close to the resting PaCOCO2. A metabolic acidosis developed in the humoral dog, although the blood flow to the perfused hindlimbs appeared to be adequate during muscular exercise. cross perfusion; neural control of respiration; humoral control of respiration; CO2 inhalation; muscle blood flow in exercise; perfusion of leg muscle Submitted on February 19, 1964
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
24 articles.
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