Respiration in man during metabolic alkalosis

Author:

Stone Daniel J.1

Affiliation:

1. Cardiopulmonary Laboratory, Veterans Administration Hospital, Bronx, New York

Abstract

A steady state metabolic alkalosis was induced in two subjects over a period of several days utilizing oral sodium bicarbonate in dosages of 50 g/day. The purpose of inducing steady state metabolic alkalosis was to study the effects of such a state on the respiratory center responses to inspired gas mixtures, containing carbon dioxide, and to contrast these results with the control studies. The experiment was so designed that the arterial pH in both subjects tended to return toward normal in the presence of significant increases in blood bicarbonate. Repeated study of ventilation responses with room air and 4% and 6% carbon dioxide in inspired air revealed a definite and significant decrease in ventilation response to carbon dioxide during the periods of steady state alkalosis as compared to the control periods. Normal responses returned after some time lag. A consistent rise in paCOCO2 occurred with alkalosis, thus demonstrating respiratory compensation. In neither subject was total lung function or gas exchange affected by the alkalosis. The experiment was confirmed on several occasions with reproducible results. Note: (With the Research Assistance of Mary Di Lieto) Submitted on May 22, 1961

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 33 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Respiratory CO2 response depends on plasma bicarbonate concentration in mechanically ventilated patients;Medicina Intensiva;2014-05

2. Clinical Syndromes of Metabolic Alkalosis;Seldin and Giebisch's The Kidney;2013

3. Rising serum sodium levels are associated with a concurrent development of metabolic alkalosis in critically ill patients;Intensive Care Medicine;2012-11-17

4. Metabolic Alkalosis;Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation;2012-09-11

5. Clinical Syndromes of Metabolic Alkalosis;Seldin and Giebisch's The Kidney;2008

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