Distensibility of small veins of the dog lung

Abstract

To determine the distensibility of the intrapulmonary veins (250–2,900 microns diam) of the dog lung, we obtained X-ray angiograms from isolated lung lobes over a vascular pressure range of approximately 0–30 Torr. Over this pressure range the diameter vs. pressure curves tended to flatten out at the high pressures. In the pressure range of 0–19 Torr, we characterized the vessel distensibility by alpha (the ratio of the slope, beta, of the graph of diameter vs. intravascular pressure to the intercept, Do). The average value of alpha was approximately 1.2%/Torr. There was a weak negative correlation (r = -0.32) between alpha and Do. Infusion of enough norepinephrine to produce approximately 50% increase in total lobar vascular resistance produced a decrease in Do and alpha of approximately 33 and 32%, respectively.