Postural baroreflex stimuli may affect EEG arousal and sleep in humans

Abstract

Past research has shown that baroreceptor stimulation can induce sleep. The present study investigated whether the upright posture inhibits sleep by reducing baroreceptor firing. Twenty-eight men were each exposed to four conditions on separate days: 40 degrees head-up tilt with (TP) and without (TN) 45 mmHg positive pressure on the legs and the supine position with (SP) and without (SN) leg pressure. Heart rate and blood pressure changes indicated that baroreceptor firing was strongly reduced by TN and only mildly reduced by TP in 24 subjects. Baroreceptor effects of SP were unclear. SN and SP did not differ significantly in their effects on electroencephalogram (EEG) sleep. Among subjects who showed a normal baroreflex response to tilt, both TN and TP inhibited sleep, but TN caused a persistent elevation of EEG beta activity that did not occur in TP plus a greater delay in sleep onset. TN had no such arousing effects in four subjects who showed little or no baroreflex response to tilt. These results are consistent with the hypothesis that the fall in baroreceptor firing produced by the upright posture contributes to EEG arousal.