Blood flow to the trachea and bronchi: the pulmonary contribution

Abstract

It is generally assumed that when pulmonary vascular pressures are normal the pulmonary contribution to central airway blood flow (Qp) is negligible compared with systemic blood flow (Qs). However, it has been suggested in recent reports that a substantial portion of central airway blood flow is Qp. We have attempted to confirm whether there is a pulmonary contribution to central airway blood flow and to describe how it is anatomically distributed. Measurements of Qp were made using the radioactive microsphere technique in anesthetized ventilated dogs (n = 7) and sheep (n = 6). Qs to the central airways was also measured in another group of sheep (n = 10). At the end of each study, animals were killed and the lungs and trachea were excised. Qp to the upper and lower trachea, mainstem bronchi, and lobar bronchi was calculated, and the relative distribution of Qp and Qs to mucosa, cartilage, and adventitia was determined. Results showed a progressive increase (P < 0.01) in Qp (in ml.min-1 x 100 g-1) from upper trachea to lobar bronchi in both dogs and sheep. Qp and Qs supplied mainly the airway adventitia and the mucosa, respectively. Expressed as a percentage, 89 +/- 4% (SE) of Qp was to the adventitia and 0.1 +/- 0.07% was to the mucosa (P < 0.01), whereas 60 +/- 3.2% of Qs was to the mucosa and 22 +/- 4.6% was to the adventitia. In conclusion, in dogs and sheep there is a pulmonary contribution to central airway blood flow that increases from upper trachea to lobar bronchi and that supplies mainly the peritracheal adventitia.