Urinary catecholamine excretion on acute induction to high altitide (3,658 m)

Abstract

Fifty healthy male volunteers, 21–34 yr of age, normally residentat altitudes less than 1,000 m, were airlifted to 3,658 m. Urinary excretion of catecholamines was measured at sea level (198 m) and on the 1st, 2nd, 4th, and 10th day of a stay at high altitude. The symptoms observed on exposure to high altitude were assigned arbitrary scores. The volunteers could,on this basis, be divided into “symptomatic” and “asymptomatic” groups. Thetwo groups showed a markedly different pattern of urinary catecholamines excretion on exposure to high altitude and on return to sea level. Significant increase in the catecholamine excretion was observed in thesymptomatic grouponly. A possible role for enhanced sympathoadrenal activity in the etiopathogenesis of high-altitude illnesses is postulated.