Differences in sodium and D-glucose transport between hamster and rat lungs

Author:

Goodman B. E.1,Anderson J. L.1,Clemens J. W.1,Kircher K. J.1,Stormo M. L.1,Waltz J. S.1,Waltz W. F.1,White J. W.1

Affiliation:

1. Department of Physiology and Pharmacology, School of Medicine, University of South Dakota, Vermillion 57069.

Abstract

The purpose of this study was to characterize phloridzin- and amiloride-sensitive transport across blood-gas barrier of hamster and rat lungs. Air spaces of isolated perfused lungs were instilled with a solution containing 22Na or L-[3H]glucose, D-[14C]glucose, and fluorescein isothiocyanate-labeled dextran. Apparent permeability-surface area products (PS) were calculated. Phloridzin (Na(+)-dependent D-glucose transport inhibitor) had no effect on D-glucose or sodium transport out of air spaces in hamster lungs. In contrast, in rat lungs, phloridzin decreased PS for D-glucose by 89% and that for Na by 28%. Trapping of 14CO2 in vascular samples was measured to estimate metabolism. Unlabeled air space D-glucose increased appearance of perfused D-[14C]glucose in air spaces of rat lungs. We conclude that Na(+)-dependent D-glucose transport is important for D-glucose uptake in rat lungs but not in hamster lungs. In hamster lungs, amiloride (Na+ transport inhibitor) also decreased PS for sodium, but drugs known to stimulate sodium transport in rat lungs had no effect. Thus, species differences in active transport processes exist in the distal air spaces of mammalian lungs.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Glucose transport in the lung and its role in liquid movement;Respiratory Physiology & Neurobiology;2007-12

2. Alveolar sodium and liquid transport in mice;American Journal of Physiology-Lung Cellular and Molecular Physiology;1999-12-01

3. Ventilator-associated Lung Injury Decreases Lung Ability to Clear Edema in Rats;American Journal of Respiratory and Critical Care Medicine;1999-02

4. Nitric oxide inhibits Na+absorption across cultured alveolar type II monolayers;American Journal of Physiology-Lung Cellular and Molecular Physiology;1998-03-01

5. Lung Edema Clearance During Hyperoxic Lung Injury;Acute Respiratory Distress Syndrome;1998

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