Release of intracellular potassium as the physiological stimulus for pain

Author:

Benjamin Fred B.1

Affiliation:

1. Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Abstract

Evidence is presented that various types of pain-producing stimuli also release intracellular potassium, and that potassium is a pain-producing stimulus. If the potassium releasing process is inhibited or neutralized by calcium, or reversed by increasing cellular uptake of potassium by means of a glucose-insulin combination, the response to painful stimuli is decreased. Calcium appears to have a more immediate effect on pain, while the effects of the glucose-insulin combination become more apparent at a later stage. When the two agents are combined there is no summation of the effect produced by each one individually. Itch is not affected by this glucose-insulin combination. It is suggested that the role of histamine in pain production is via the potassium releasing process. Evidence is considered to indicate that the major effect of a noxious stimulus is not the direct effect on the pain receptor but indirect due to the tissue reaction. Submitted on August 26, 1958

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Iontophoretically applied potassium ions as an experimental pain stimulus for investigating pain mechanisms;Perception & Psychophysics;1994-11

2. Pain and Nociception;Comprehensive Physiology;1984-12

3. Pain and Inflammatory Mediators;Inflammation;1978

4. HISTAMINE AS THE CHEMICAL MEDIATOR FOR CUTANEOUS PAIN;Journal of Investigative Dermatology;1977-07

5. CHEMICAL CAUSES OF PAIN AND ITCH;Annual Review of Medicine;1970-02

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