Affiliation:
1. Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Abstract
Evidence is presented that various types of pain-producing stimuli also release intracellular potassium, and that potassium is a pain-producing stimulus. If the potassium releasing process is inhibited or neutralized by calcium, or reversed by increasing cellular uptake of potassium by means of a glucose-insulin combination, the response to painful stimuli is decreased. Calcium appears to have a more immediate effect on pain, while the effects of the glucose-insulin combination become more apparent at a later stage. When the two agents are combined there is no summation of the effect produced by each one individually. Itch is not affected by this glucose-insulin combination. It is suggested that the role of histamine in pain production is via the potassium releasing process. Evidence is considered to indicate that the major effect of a noxious stimulus is not the direct effect on the pain receptor but indirect due to the tissue reaction. Submitted on August 26, 1958
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
10 articles.
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