Affiliation:
1. Cardiovascular Research Institute, University of California Medical Center, San Francisco, California; and Department of Physiology, University of Pennsylvania Graduate School of Medicine, Philadelphia, Pennsylvania
Abstract
We have determined the over-all association rate constant, k'c, for the uptake of oxygen by normal human erythrocytes from 0% to 97% initial hemoglobin saturation at pH 7.4 and 37óC. With a modified Hartridge-Roughton rapid-reaction apparatus, we used a small oxygen electrode to follow the oxygen uptake process rather than using the usual photocolorimetric analytical methods. The value of k'c averages 164 mm-1 sec.-1 at 0% initial saturation, rises slowly to over 300 at 50%, and then climbs rapidly to over 1500 at 95%. The theoretical explanation for the increase in k-c with rising initial oxyhemoglobin saturation is based on the increasing prominence of the fourth chemical association rate constant, k-4, in the intermediate compound theory of Adair. It is known that k-4 is several times larger than any of the other three k–s. Submitted on December 19, 1960
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
83 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Metabolic Modeling in Altered Gravity;2020 IEEE Aerospace Conference;2020-03
2. Gas Exchange at Rest and during Exercise in Mammals;Comparative Biology of the Normal Lung;2015
3. Mathematical Modelling of Pulmonary Gas Exchange;Modelling Methodology for Physiology and Medicine;2014
4. Pulmonary Gas Exchange and Acid‐Base Balance During Exercise;Comprehensive Physiology;2013-04
5. Diffusion of respiratory gases;Nunn's Applied Respiratory Physiology;2010