Bronchial vasodilatory response to ionic and nonionic contrast media

Abstract

Baile, Elisabeth M., Lu Wang, Lorraine Verburgt, and Peter D. Paré. Bronchial vasodilatory response to ionic and nonionic contrast media. J. Appl. Physiol. 82(3): 841–845, 1997.—It has recently been shown that bronchial arterial injection of conventional contrast medium causes a significant increase in bronchial blood flow (Q˙br) and that this response is partially attenuated after infusion of N ω-nitro-l-arginine (l-NNA). However, the precise mechanism for this increase in Q˙br is unknown. In this study we examined the effect of bronchial arterial injection of conventional ionic as well as nonionic contrast media. We measuredQ˙br in nine anesthetized, ventilated, open-chest sheep. Q˙br was recorded before (baseline) and at the peak response to injection of 0.5 ml of either 0.9% saline (control; isosmolar with plasma), Omnipaque 300 (iohexol; nonionic), Conray 66 (sodium iothalamate; ionic), or 50% dextrose (viscous control).