Acid-base changes in the fetal lamb before and after lung expansion

Author:

Assali N. S.1,Manson W. A.1,Holm L. W.1,Ross M.1

Affiliation:

1. Departments of Obstetrics and Gynecology and of Physiology, University of California School of Medicine, Los Angeles, and Department of Physiology, University of California School of Veterinary Medicine, Davis, California

Abstract

The acid-base status of the fetal lamb was studied in near-term pregnant ewes subjected to spinal anesthesia. The status of the fetus was compared to its mother and the changes which occur after the fetal lungs were ventilated with oxygen or nitrogen were investigated. The results show that: 1) the fetus in utero is in a state of metabolic acidosis in relation to the mother, 2) the acidosis does not seem to be related to the fetal blood pCO2, and 3) the acidosis may be aggravated by hypoxia. fetal acidosis; blood pH; blood oxygen; blood carbon dioxide; hypoxia; hyperoxia; sheep Submitted on March 20, 1963

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 12 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Pulmonary Angiographic Patterns in Fetal Lambs;Investigative Radiology;1971-11

2. Placental Transfer of a Substituted Pteridine from Fetus to Mother;Science;1970-02-13

3. TECHNIQUES FOR THE LONG-TERM COLLECTION OF LYMPH FROM THE UNANAESTHETIZED FOETAL LAMB IN UTERO;Australian Journal of Experimental Biology and Medical Science;1969-10

4. Fetal and neonatal response to acid loading in the sheep.;Journal of Applied Physiology;1968-02

5. Gas exchange in the pregnant uterus;Physiological Reviews;1967-10-01

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