Affiliation:
1. Departments of Internal Medicine and Pharmacology and Pediatrics, University of California, Davis, California 95616
Abstract
Bonham, A. C., K. S. Kott, and J. P. Joad. Sidestream smoke exposure enhances rapidly adapting receptor responses to substance P in young guinea pigs. J. Appl. Physiol. 81(4): 1715–1722, 1996.—We determined the effect of sidestream tobacco smoke (SS) exposure on responses of lung rapidly adapting receptors (RARs), peak tracheal pressure (Ptr), and arterial blood pressure (ABP) to substance P in young guinea pigs. Guinea pigs were exposed to SS or filtered air from day 8 to days 41–45 of life. They were then anesthetized and given three doses of intravenous substance P (1.56–4.94 nmol/kg). SS exposure augmented substance P-evoked increases in RAR activity ( P = 0.029 by analysis of variance) but not substance P-evoked increases in peak Ptr or decreases in ABP. Neurokinin 1-receptor blockade (CP-96345, 400 nmol/kg) attenuated substance P-evoked increases in RAR activity ( P = 0.001) and ABP ( P = 0.009) but not in peak Ptr ( P = 0.06). Thus chronic exposure to SS in young guinea pigs exaggerates RAR responsiveness to substance P. The findings may help explain the increased incidence of airway hyperresponsiveness and cough in children chronically exposed to environmental tobacco smoke.
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
30 articles.
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