Increases in plasma beta-endorphin/beta-lipotropin immunoreactivity after treadmill running in humans

Author:

Farrell P. A.,Gates W. K.,Maksud M. G.,Morgan W. P.

Abstract

Six well-trained endurance athletes were studied to determine if submaximal treadmill exercise results in increased plasma levels of beta-endorphin/beta-lipotropin (Bh-Ep/Bh-LPH) immunoreactivity. Bh-Ep/Bh-LPH immunoreactivity was measured by radio immunoassay in plasma from six experienced runners before and after 30-min treadmill runs at a self-selected pace, 60 and 80% VO2 max, and a control experiment of 30 min rest. All tests were randomized and occurred during the same time of day for a given subject (0600--1500 h). Preexercise Bh-Ep/Bh-LPH values averaged between 10 and 20 pg/ml and increased two- to fivefold after each run. The increase was statistically significant (P less than 0.05) only after the 60% run when Bh-Ep/Bh-LPH increased to a mean of 58.3 pg/ml. A large individual variation in the Bh-Ep/Bh-LPH response to running was noted. Mood state and perceptual data were also collected, and no significant relationship with Bh-Ep/Bh-LPH was evident. These data suggest that the stress of treadmill running acts as a stimulus to greater Bh-Ep/Bh-LPH secretion, a reduction in its degradation, or a combination of these, which leads to increased levels of these ligands in venous blood. The physiological significance of these increased plasma levels is not clear.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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