Pulmonary resistance and compliance with concurrent radioactive sulfur distribution in dogs breathing S35O2

Abstract

Ten dogs breathed S35O2 via a tracheal cannula in concentrations ranging from 1.8 to 148 p p.m. There was a decrease in the compliance of the lungs and thorax after 10–15 minutes of inhalation, and an immediate and marked increase in the nonelastic resistance to breathing. S35 was found to be highest in concentration in the trachea, lungs, and hilar lymph nodes, and next highest in the kidneys and esophagus. A relatively uniform and low concentration was noted in other tissues, such as the heart muscle, liver, spleen and striated muscle. S35O2 when inhaled was absorbed quickly, distributed widely to many tissues and readily gained access to many tissues, including the brain. Submitted on April 28, 1959