Electrical and mechanical changes in immobilized human muscle

Abstract

After forearm fracture, the human thumb was unilaterally immobilized in eight subjects for 6 wk in a standard plaster cast. Changes of contraction properties were studied in the adductor pollicis muscle. The contralateral muscle remained unrestrained and served as control. After immobilization, the maximal voluntary contraction was reduced by 55% (P less than 0.05), and the electrically evoked maximal tetanic contraction (Po) was reduced by 33% (P less than 0.05). The decrease of Po was associated with increased maximal rate of tension development (10%) and decreased maximal rate of tension relaxation (22%). The twitch times to peak and to half relaxation were increased by 16 and 14%, respectively, but the twitch tension (Pt) was not significantly changed and the Pt/Po ratio was increased by 43% after immobilization. The muscle surface action potential presented an increase of its duration (19%) and a decrease of the amplitude and the total area (15 and 26%, respectively). The comparison of the electrical and mechanical alterations recorded during voluntary contractions, and in contractions evoked by electrical stimulation of the motor nerve, suggests that immobilization not only modifies the peripheral processes associated with contraction but also changes central and/or neural command of the contraction. At peripheral sites, it is proposed that the intracellular processes of contraction play the major role in the contractile impairment recorded during immobilization.