Angiotensin I conversion and vascular reactivity in pathophysiological states in dogs

Author:

Leuenberger P. J.,Stalcup S. A.,Greenbaum L. M.,Mellins R. B.,Turino G. M.

Abstract

To determine if angiotension converting enzyme activity is altered by acute pathophysiological insults, we assessed angiotensin I conversion using a blood pressure response technique in anesthetized dogs studied during acute 100% O2 breathing and acute acid-base derangements. Also, we determined systemic vascular reactivity to angiotensin II by measuring the magnitude and duration of the arterial blood pressure response to intra-arterial injections of angiotensin II under these same conditions. Angiotensin I conversion found in normoxia [91 +/- 7 (SD)%] was unchanged by acute acidosis, alkalosis, and hyperoxia. During acute hyperoxia the mean half time of the hypertensive response increased from 68 +/- 25 (SD) s at a PaO2 of 112 +/- 18 (SD) Torr to 100 +/- 34 (SD) s at a PaO2 of 491 +/- 47 (SD) Torr (P less than 0.01). No other pathophysiological condition studied had any effect on reactivity of systemic vasculature to angiotensin II. We conclude that, except during acute hypoxia as previously shown, converting enzyme activity is resistant to other pathophysiological insults and that vascular responsiveness to angiotensin II is enhanced by hyperoxia.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Modulation of Converting Enzyme Activity by Hypoxia and Its Physiological Effects;Ciba Foundation Symposium 78 - Metabolic Activities of the Lung;2008-05-30

2. Angiotensin-converting enzyme activity in the isolated perfused guinea pig lung;Journal of Pharmacological Methods;1990-04

3. Effects of angiotensin II on arterial pressure, renin and aldosterone during exercise;European Journal of Applied Physiology and Occupational Physiology;1985-09

4. Research in pediatric surgery;World Journal of Surgery;1985-04

5. ENDOTHELIAL CELL FUNCTIONS IN THE HEMODYNAMIC RESPONSES TO STRESS;Annals of the New York Academy of Sciences;1982-12

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