Two classic papers in acid-base physiology: contributions of R. F. Pitts, R. S. Alexander, and W. D. Lotspeich

Author:

Giebisch Gerhard

Abstract

This essay looks at the historical significance of two APS classic papers that are freely available online:Pitts RF and Alexander RS. The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol 144: 239—254, 1945 ( http://ajplegacy.physiology.org/cgi/reprint/144/2/239 ).Pitts RF and Lotspeich WD. Bicarbonate and the renal regulation of acid base balance. Am J Physiol 147: 138—154, 1946 ( http://ajplegacy.physiology.org/cgi/reprint/147/1/138 ).

Publisher

American Physiological Society

Subject

Physiology

Reference10 articles.

1. Alexander RS.Pitts and urine acidification.Physiologist26: 364–366, 1983.

2. Berliner RWand Giebisch GH.Robert Franklin Pitts, 1908–1977.Biographical Memoirs.Washington, DC: National Academy Press, 1987,vol. 57, p. 322–344.

3. The Scientific Achievements of R.F. Pitts and V. du Vigneaud

4. Henderson LJ.A critical study of the process of acid excretion.J Biol Chem9: 403–404, 1911.

5. Pitts RF.Some aphorisms on research and writing.Yale J Biol Med43: 331–336, 1971.

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