Machine learning approaches reveal subtle differences in breathing and sleep fragmentation in Phox2b-derived astrocytes ablated mice

Author:

Silva Talita M.12,Borniger Jeremy C.3,Alves Michele Joana1,Alzate Correa Diego1,Zhao Jing4,Fadda Paolo5ORCID,Toland Amanda Ewart56,Takakura Ana C.7,Moreira Thiago S.2,Czeisler Catherine M.1,Otero José Javier1ORCID

Affiliation:

1. Division of Neuropathology, Department of Pathology, The Ohio State University College of Medicine

2. Department of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo

3. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

4. Department of Biomedical Informatics, The Ohio State University College of Dentistry

5. Genomics Shared Resource-Comprehensive Cancer Center, The Ohio State University

6. Department of Cancer Biology and Genetics, The Ohio State University College of Medicine

7. Department of Pharmacology, Institute of Biomedical Science, University of São Paulo

Abstract

ML/AI classification workflows are capable of providing insight into differences between genotypes for neurophysiology research. Analytical techniques utilized in the neurophysiology community can be augmented by implementing ML/AI workflows. Random forest is a robust classification algorithm for respiratory plethysmography data. Utilization of ML/AI workflows in neurophysiology research requires heightened transparency and improved community research standards.

Funder

Fapesp

National Instiute of Health

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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