Long-Term Adaptation Mechanisms in Extremity Veins Supporting Orthostatic Tolerance

Author:

Monos Emil1,Lóránt Miklós1,Dörnyei Gabriella1,Bérczi Viktor2,Nádasy György1

Affiliation:

1. Institute of Human Physiology and Experimental Research and

2. Department of Cardiovascular Surgery, Semmelweis University Budapest, 1082 Budapest, Hungary

Abstract

Several long-term antigravity defense mechanisms are activated in the lower extremity veins and microvessels when an organism is exposed to chronic orthostatic load. These mechanisms involve acute pressure-induced myogenic response, counterregulatory K+ channels, functional and structural remodeling of sympathetic innervation, and vascular network properties.

Publisher

American Physiological Society

Subject

Physiology

Reference19 articles.

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2. Myogenic responses of isolated rat skeletal muscle venules: modulation by norepinephrine and endothelium

3. Dörnyei G, Nádasy GL, and Monos E. Myogenic tone of rat saphenous vein is reduced by head-down gravitational stress (Abstract).Acta Physiol Hung 89: 92, 2002.

4. Biomechanical response of femoral vein to chronic elevation of blood pressure in rabbits

5. Hudlicka O, Dörnyei G, and Monos E. The effect of long-term tilting on capillary supply in rat hind limb muscles.Acta Physiol Hung 83: 205–212, 1995.

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