Perinatal Western-style diet exposure associated with decreased microglial counts throughout the arcuate nucleus of the hypothalamus in Japanese macaques-Reference-Cited by-同舟云学术

Perinatal Western-style diet exposure associated with decreased microglial counts throughout the arcuate nucleus of the hypothalamus in Japanese macaques

Published:2024-02-01 Issue:2 Volume:131 Page:241-260
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Papadakis Samantha¹²^ORCID,Thompson Jacqueline R.³,Feczko Eric⁴⁵,Miranda-Dominguez Oscar⁴⁵^ORCID,Dunn Geoffrey A.⁶,Selby Matthew⁶,Mitchell AJ¹³,Sullivan Elinor L.¹²³,Fair Damien A.⁴⁵⁷

Affiliation:

1. Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, United States

2. Department of Psychiatry, Oregon Health & Science University, Portland, Oregon, United States

3. Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States

4. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, United States

5. Masonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, Minnesota, United States

6. Department of Human Physiology, University of Oregon, Eugene, Oregon, United States

7. Institute of Child Development, College of Education and Human Development, University of Minnesota, Minneapolis, Minnesota, United States

Abstract

Prenatal Western-style diet exposure is associated with increased microglial activity in utero. However, we found a potentially neuroprotective reduction in microglia count during early postnatal development. This trajectory could inform the timing of disruptions to microglia-mediated neuronal circuit formation. Additionally, this is the first study in juvenile macaques to characterize the distribution of microglia along the rostral-caudal axis of the arcuate nucleus of the hypothalamus. Nearby neuronal populations may be greater targets during inflammatory insults.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00213.2023

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3. Changes in Melanocortin Expression and Inflammatory Pathways in Fetal Offspring of Nonhuman Primates Fed a High-Fat Diet

4. Maternal Western-style diet reduces social engagement and increases idiosyncratic behavior in Japanese macaque offspring

5. Chronic Consumption of a High-Fat Diet during Pregnancy Causes Perturbations in the Serotonergic System and Increased Anxiety-Like Behavior in Nonhuman Primate Offspring

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