P-sort: an open-source software for cerebellar neurophysiology-Reference-Cited by-同舟云学术

P-sort: an open-source software for cerebellar neurophysiology

Published:2021-10-01 Issue:4 Volume:126 Page:1055-1075
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Sedaghat-Nejad Ehsan¹^ORCID,Fakharian Mohammad Amin¹²^ORCID,Pi Jay¹^ORCID,Hage Paul¹^ORCID,Kojima Yoshiko³^ORCID,Soetedjo Robi⁴,Ohmae Shogo⁵^ORCID,Medina Javier F.⁵,Shadmehr Reza¹^ORCID

Affiliation:

1. Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland

2. School of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran

3. Department of Otolaryngology—Head and Neck Surgery, Washington National Primate Center, University of Washington, Seattle, Washington

4. Department of Physiology and Biophysics, Washington National Primate Center, University of Washington, Seattle, Washington

5. Memory and Brain Research Center, Dept. of Neuroscience, Baylor College of Medicine, Houston, Texas

Abstract

Algorithms that perform spike sorting depend on waveforms to cluster spikes. However, a cerebellar Purkinje-cell produces two types of spikes; simple and complex spikes. A complex spike coincides with the suppression of generating simple spikes. Here, we recorded neurophysiological data from three species and developed a spike analysis software named P-sort that relies on this statistical property to improve both the detection and the attribution of simple and complex spikes in the cerebellum.

Funder

DOD | US Navy | Office of Naval Research

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | National Eye Institute

HHS | NIH | NIH Office of the Director

HHS | NIH | National Institute of Mental Health

National Science Foundation

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience