The Discovery of Renin 100 Years Ago

Author:

Phillips M. Ian1,Schmidt-Ott K. M.1

Affiliation:

1. M. I. Phillips and K. M. Schmidt-Ott are in the Department of Physiology of the University of Florida College of Medicine, Box 100274, Gainesville, FL 32610

Abstract

In 1898, Tigerstedt and Bergman published their observation that kidney extracts produce pressor effects. They characterized the substance and named it “renin.” Although this was the beginning of understanding the role of the kidney in hypertension and the renin-angiotensin system, their discovery lay dormant for nearly 40 years.

Publisher

American Physiological Society

Subject

Physiology

Reference9 articles.

1. Bingel, A. and E. Strauss. Uber die blutdrucksteigernde Substanz der Niere. Dtsch. Arch. Klin. Med. 96: 476–492, 1909.

2. Braun-Menendez, E., and I. H. Page. Suggested revision of nomenclature: angiotensin. Science 127: 242, 1958.

3. Brown-Sequard, C. E. Demonstrant la puissance dynamogenique chez l'homme d'un liquide extrait de testicules d'animaux. Arch. Phys. Norm. Pathol. 21: 651–658, 1889.

4. Brown-Sequard, C. E., and A. d'Arsonnval. Des injections sous-cutanees ou intraveineuses d'extraits liquides de nombre d'organes, comme methode therapeutique. C. R. Acad. Sci. 64: 1399–1404, 1892.

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