An Integrated View of Insect Flight Muscle: Genes, Motor Molecules, and Motion-Reference-Cited by-同舟云学术

An Integrated View of Insect Flight Muscle: Genes, Motor Molecules, and Motion

Published:1999-06 Issue:3 Volume:14 Page:87-92
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Maughan David W.¹,Vigoreaux Jim O.¹

Affiliation:

1. D. W. Maughan and J. O. Vigoreaux are in the Department of Molecular Physiology & Biophysics and the Department of Biology, respectively, of the University of Vermont, Burlington, VT 05405, USA.

Abstract

Substituting an alanine for serine in the regulatory subunit of the motor protein myosin dramatically alters Drosophila's flight ability. Power output, at all levels of the flight system, is reduced. This example of deciphering a protein's function by producing malfunctions illustrates the broadening use of molecular genetics in integrative biology.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.1999.14.3.87

Reference15 articles.

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2. Phosphorylation-dependent power output of transgenic flies: an integrated study

3. Dickinson, M. H., and M. S. Tu. The function of Dipteran flight muscle. Comp. Biochem. Physiol. 116A: 223–238, 1997.

4. Homyk, T., and C. P. Emerson. Functional interactions between unlinked muscle genes within haploinsufficient regions of the Drosophila genome. Genetics 119: 105–121, 1988.

5. Irving, M., and G. Piazzesi. Motions of myosin heads that drive muscle contraction. News Physiol. Sci. 12: 249–254, 1997.

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