From Funny Current to HCN Channels: 20 Years of Excitation-Reference-Cited by-同舟云学术

From Funny Current to HCN Channels: 20 Years of Excitation

Published:2002-02 Issue:1 Volume:17 Page:32-37
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Accili E. A.¹,Proenza C.¹,Baruscotti M.²,DiFrancesco D.²³

Affiliation:

1. School of Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada

2. Dipartimento di Fisiologia e Biochimica Generali, Laboratorio di Fisiologia Molecolare e Neurobiologia and

3. Istituto Nazionale per la Fisica della Materia, Unità Milano Universita, 20133 Milano, Italy; and

Abstract

The “funny” (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K+ and Na+, modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.2002.17.1.32

Reference19 articles.

1. Properties and modulation of If in newborn versus adult cardiac SA node

2. Altomare C, Bucchi A, Camatini E, Baruscotti M, Viscomi C, Moroni A, and DiFrancesco D. Integrated allosteric model of voltage gating in HCN channels. J Gen Physiol 17: 519–532, 2001.

3. Action of internal pronase on the f‐channel kinetics in the rabbit SA node

4. Functional Roles of Charged Residues in the Putative Voltage Sensor of the HCN2 Pacemaker Channel

5. Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide

Cited by 170 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Non-paroxysmal junctional tachycardia complicating disseminated intravascular coagulation during massive surgical hemorrhage: A case report;Medicine;2024-04-05

2. Pacemaking in the lymphatic system;The Journal of Physiology;2024-03-23

3. The enigmatic HCN channels: A cellular neurophysiology perspective;Proteins: Structure, Function, and Bioinformatics;2023-11-19

4. Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons;The Journal of Neuroscience;2023-08-09

5. The role of P21-activated kinase (Pak1) in sinus node function;Journal of Molecular and Cellular Cardiology;2023-06