Affiliation:
1. Institute of Physiology, Medical University of Luebeck, D-23538 Luebeck, Germany
Abstract
The glycoprotein thrombopoietin (TPO) is the major stimulator of megakaryopoiesis and platelet production. Hepatocytes express TPO mRNA at a constant rate. The plasma TPO level is inversely correlated to the mass of megakaryocytes and platelets, which degrade the hormone following its binding to specific membrane receptors.
Publisher
American Physiological Society
Cited by
9 articles.
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