Human Myoblast Differentiation: Ca2+ Channels are Activated by K+ Channels-Reference-Cited by-同舟云学术

Human Myoblast Differentiation: Ca2+ Channels are Activated by K+ Channels

Published:2002-02 Issue:1 Volume:17 Page:22-26
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Bernheim Laurent¹,Bader Charles R.²

Affiliation:

1. Département de Physiologie, Centre Médical Universitaire, and

2. Division de Recherche Clinique Neuro-Musculaire, Département des Neurosciences Cliniques et Dermatologie, Hôpital Cantonal Universitaire, CH-1211 Geneva 4, Switzerland

Abstract

In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca2+ influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K+ channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca2+ current (mediated by a1H T-type Ca2+ channels), which causes intracellular Ca2+ to rise.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.2002.17.1.22

Reference19 articles.

1. Bernheim L, Liu JH, Hamann M, Haenggeli CA, Fischer-Lougheed J, and Bader CR. Contribution of a non-inactivating potassium current to the resting potential of fusion-competent human myoblasts. J Physiol (Lond) 493: 129–141, 1996.

2. T-type alpha 1H Ca2+ channels are involved in Ca2+ signaling during terminal differentiation (fusion) of human myoblasts

3. Anether -à-go-goK+current,Ih-eag, contributes to the hyperpolarization of human fusion-competent myoblasts

4. TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

5. Brandt P and Vanaman TC. Splicing of the muscle-specific plasma membrane Ca2+-ATPase isoforms PMCA1c is associated with cell fusion in C2 myocytes. J Neurochem 62: 799–802, 1994.

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