Atrial Natriuretic Peptide: Regulator of Chronic Arterial Blood Pressure-Reference-Cited by-同舟云学术

Atrial Natriuretic Peptide: Regulator of Chronic Arterial Blood Pressure

Published:2000-06 Issue:3 Volume:15 Page:143-149
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Melo Luis Gabriel¹,Pang Stephen C.¹,Ackermann Uwe¹

Affiliation:

1. L. G. Melo and U. Ackermann are in the Department of Physiology of the University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. S. C. Pang is in the Department of Anatomy and Cell Biology, Faculty of Health Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.

Abstract

Recent findings in atrial natriuretic peptide (ANP) transgenic and gene knockout mouse models uncovered a tonic vasodilatory effect of this hormone that contributes to chronic blood pressure homeostasis. With elevated salt intake, ANP-mediated antagonism of the renin-angiotensin system is essential for blood pressure constancy, suggesting that a deficiency in ANP activity may underlie the etiology of sodium-retaining disorders.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.2000.15.3.143

Reference15 articles.

1. Hemodynamics in transgenic mice with overexpression of atrial natriuretic factor.

2. Diverse biological actions of atrial natriuretic peptide

3. Changes of regional blood flow induced by atrial natriuretic factor (ANF) in conscious rats

4. Chronic vs. acute hemodynamic effects of atrial natriuretic factor in conscious rats

5. Effect of saline infusion on kidney and collecting duct function in atrial natriuretic peptide (ANP) gene "knockout" mice

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