Mechanics of Relaxation of the Human Heart-Reference-Cited by-同舟云学术

Mechanics of Relaxation of the Human Heart

Published:2000-04 Issue:2 Volume:15 Page:78-83
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Chemla Denis¹,Coirault Catherine¹,Hébert Jean-Louis¹,Lecarpentier Yves¹

Affiliation:

1. D. Chemla, C. Coirault, J.-L. Hébert, and Y. Lecarpentier are in the Service de Physiologie Cardio-Respiratoire, CHU de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94 275 Le Kremlin-Bicêtre, and Unité Inserm U451-Loa-Ensta-Ecole Polytechnique, 91 125 Palaiseau, France.

Abstract

Rapid and complete relaxation is a prerequisite for cardiac output adaptation to changes in loading conditions, inotropic stimulation, and heart rate. In the healthy human heart, the rate and extent of relaxation depend mainly on actomyosin cross bridge dissociation and on left ventricular end-systolic volume, rather than on the afterload level.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.2000.15.2.78

Reference13 articles.

1. Relaxation and diastole of the heart

2. Relationship between inotropy and relaxation in rat myocardium

4. Are contraction and relaxation coupled in patients with and without congestive heart failure?

5. Myocardial relaxation. II. Hemodynamic determinants of rate of left ventricular isovolumic pressure decline

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