Endothelium-Derived Hyperpolarizing Factor—Fact or Fiction?-Reference-Cited by-同舟云学术

Endothelium-Derived Hyperpolarizing Factor—Fact or Fiction?

Published:2000-02 Issue:1 Volume:15 Page:1-5
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Hecker Markus¹

Affiliation:

1. M. Hecker is a professor in and Director of the Department of Cardiovascular Physiology, University of Goettingen, Humboldtallee 23, 37073 Goettingen, Germany.

Abstract

The vascular endothelium releases a diffusible factor that hyperpolarizes and hence relaxes vascular smooth muscle cells predominantly through activation of Ca2+-dependent K+ channels. In the coronary circulation, this endothelium-derived hyperpolarizing factor appears to be a cytochrome P450-derived arachidonic acid epoxide, the release of which may play a crucial role in the maintenance of coronary blood flow in arteriosclerosis.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.2000.15.1.1

Reference15 articles.

1. Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors

2. Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries

3. Endothelium-Dependent Hyperpolarization

4. K+ is an endothelium-derived hyperpolarizing factor in rat arteries

5. Endothelium-dependent hyperpolarization: a role in the control of vascular tone

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