ATP-Sensitive Potassium Channels in Dopaminergic Neurons: Transducers of Mitochondrial Dysfunction-Reference-Cited by-同舟云学术

ATP-Sensitive Potassium Channels in Dopaminergic Neurons: Transducers of Mitochondrial Dysfunction

Published:2001-10 Issue:5 Volume:16 Page:214-217
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Liss Birgit¹,Roeper Jochen¹

Affiliation:

1. MRC Anatomical Neuropharmacology Unit, University of Oxford, OX1 3TH Oxford, UK

Abstract

ATP-sensitive potassium (KATP) channels directly couple the metabolic state of a cell to its electrical activity. Dopaminergic midbrain neurons express alternative types of KATP channels mediating their differential response to mitochondrial complex I inhibition. Because reduced complex I activity is present in Parkinson's Disease, differential KATP channel expression suggests a novel candidate mechanism for selective dopaminergic degeneration.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.2001.16.5.214

Reference17 articles.

1. Aguilar-Bryan L and Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr Rev 20: 101–135, 1999.

2. Correlating structure and function in ATP-sensitive K+ channels

3. PIP 2 and PIP as Determinants for ATP Inhibition of K ATP Channels

4. Chronic systemic pesticide exposure reproduces features of Parkinson's disease

5. KATP channel openers, adenosine agonists and epileptic preconditioning are stress signals inducing hippocampal neuroprotection

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