Dysregulation of Intestinal Mucosal Immunity: Implications in Inflammatory Bowel Disease

Author:

Laroux F. Stephen1,Pavlick Kevin P.1,Wolf Robert E.2,Grisham Matthew B.1

Affiliation:

1. Departments of Molecular and Cellular Physiology and

2. Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932

Abstract

The mucosal interstitia of the intestine and colon are continuously exposed to large amounts of dietary and microbial antigens. Fortunately, the mucosal immune system has evolved efficient mechanisms to distinguish potentially pathogenic from nonpathological antigens. There are, however, situations in which this immune regulation fails, resulting in chronic gut inflammation.

Publisher

American Physiological Society

Subject

Physiology

Reference16 articles.

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