Preeclampsia: Linking Placental Ischemia with Cardiovascular-Renal Dysfunction-Reference-Cited by-同舟云学术

Preeclampsia: Linking Placental Ischemia with Cardiovascular-Renal Dysfunction

Published:2001-12 Issue:6 Volume:16 Page:282-286
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Alexander Barbara T.¹,Bennett William A.¹,Khalil Raouf A.¹,Granger Joey P.¹

Affiliation:

1. Departments of Physiology and Obstetrics and Gynecology, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505

Abstract

Placental ischemia during preeclampsia is thought to lead to widespread activation/dysfunction of the maternal vascular endothelium. This results in enhanced formation of endothelin and thromboxane and decreased formation of nitric oxide and prostacyclin. These endothelial abnormalities, in turn, cause hypertension by impairing renal pressure natriuresis and increasing total peripheral resistance.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.2001.16.6.282

Reference19 articles.

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3. Reduced Uterine Perfusion Pressure During Pregnancy in the Rat Is Associated With Increases in Arterial Pressure and Changes in Renal Nitric Oxide

4. Differential Expression of Renal Nitric Oxide Synthase Isoforms During Pregnancy in Rats

5. Endothelin Type A Receptor Blockade Attenuates the Hypertension in Response to Chronic Reductions in Uterine Perfusion Pressure

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