Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10-Reference-Cited by-同舟云学术

Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10

Published:2024-04-01 Issue:4 Volume:326 Page:C1042-C1053
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Nakamura Yoshinobu¹^ORCID,Ito Masa-aki²,Hoshino Yukino¹,Matsuoka Isao²,Okada Toshiaki³,Okada Yasunobu⁴^ORCID,Nakanishi Takeo¹^ORCID

Affiliation:

1. Laboratory for Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Japan

2. Laboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Japan

3. Veneno Technologies Co. Ltd., Tsukuba, Japan

4. National Institute for Physiological Sciences (NIPS), Okazaki, Japan

Abstract

A previous study indicated that the ANXA2/S100A10 complex represents the regulatory component of SLCO2A1-mediated Maxi-Cl channel activity. The present study showed that apparent PGE2 uptake by C127 cells was osmoinsensitive and uncompetitively inhibited by loss of ANXA2 expression, demonstrating that ANXA2 is a regulatory factor of SLCO2A1-mediated PG transport activity.

Funder

Takasaki University of Health and Welfare

Japan Tobacco Inc.

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00701.2023

Reference45 articles.

1. Failure of Postnatal Ductus Arteriosus Closure in Prostaglandin Transporter–Deficient Mice

2. Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action

3. Prostaglandin transport

4. Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT

5. The Two-Step Model of Prostaglandin Signal Termination: In Vitro Reconstitution with the Prostaglandin Transporter and Prostaglandin 15 Dehydrogenase